The Center for Image-Guided Neurosurgery incorporates the expertise of individuals in stereotactic and functional neurosurgery, brain tumor surgery, Gamma Knife radiosurgery, neuro-oncology, radiation oncology, and neuroradiology. The goal of the center is to provide quality patient care using minimal access or minimally invasive techniques that utilize stereotactic and radiosurgery technology, high resolution neuroimaging, and advanced computer systems. The center provides care to patients with brain tumors, vascular disorders, movement disorders, and pain problems.

Since 1981, the center has been an international source for innovative technology development in neurosurgery, employing the first intraoperative CT scanner and the first North American 201 Source Gamma Knife. It has been a leader in both frame-based and frameless guided surgery. More than 1000 patients annually undergo surgery at the center. The center's faculty also conduct clinical studies related to advanced brain tumor management, vascular disorders and functional problems. Research interests include the integration of advanced imaging techniques into neurosurgery and studies of the radiobiology of focused tumor irradiation. In 1996, the first United States B-type Gamma Knife was added, and in 2000, the first model C Gamma Knife. The model 4C Gamma Knife was installed in 2004 and the Perfexion® Gamma Knife in September 2007.